Plasmodium falciparum, one of the most deadly human malaria parasites, consistently has evolved resistance to antimalarials that have been intensively used. The genetic basis of resistance to chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) has been most completely studied. The genes associated with the resistance to each drug are different, but in each case, a few single-nucleotide polymorphisms (SNPs) in 1 or 2 genes were shown to be responsible. These SNPs were then used as molecular markers to trace retrospectively the path of the resistant parasites. For both CQ and SP, these parasites spread from very few points of origin that included the northwest region of Cambodia in Southeast Asia. Studies showed that parasites with the molecular markers were present far from this origin long before intensive drug use increased their prevalence, resulting in high levels of treatment failure. Even more remarkable, each resistant population was introduced from Southeast Asia into East Africa by individuals carrying the resistant strain and then spread throughout the continent more »
The Rwanda Biomedical Center has announced new efforts to help eliminate malaria in the country.
The Minister of Health and Social Welfare, Dr. Omar Sey, has said the application of cost-effective multiple interventions in The Gambia has culminated in registering a lot of achievements in preventing and controlling malaria in the country.
Genocea Biosciences announced the receipt of a $1.2 million grant from the Bill & Melinda Gates Foundation for the identification of protective T cell antigens for malaria vaccines.
The World Health Organization (WHO) has declared, "A post-antibiotic era—in which common infections and minor injuries can kill—far from being an apocalyptic fantasy, is instead a very real possibility for the 21st century".
Last year, Prof Henk Bouwman of North-West University and co-authors published a paper in a respectable journal, Environmental Research, claiming that DDT spraying led to thinning of bird eggshells.
The environmental science journal Environmental Research has published an article by nine malaria experts exposing major errors in a research paper on DDT and bird eggshells.
In Southern Africa, the malaria season typically begins with the summer rains in November and ends in April. In this region, the co-ordination of malaria control efforts between neighbouring states has dramatically reduced the incidence of malaria.
Al Jazeera's report by Mara Kardas-Nelson (DDT's pesky proponents Apr. 21, 2014) rakes over old ground and is replete with misstatements and falsehoods.Read more »
Zimbabweans stand to gain access to better medicines after the World Health Organization's (WHO's) approval, this week, of a medicines quality control laboratory in Harare.
A genetic region responsible for red blood cell invasion was among a small number of areas found to differ between the genomes of malaria parasites that affect chimpanzees and Plasmodium falciparum, the parasite responsible for the deaths of more than half a million children each year.
Is attacking the mosquito or curing the patient the best way to manage this disease? Join The Guardian debate on 11 September, 1-3pm BST
Over the past several decades, malaria diagnosis has changed very little.
The head of the US Agency for International Development said on Tuesday poor understanding of Ebola was undermining the fight against the epidemic, pointing out that the fever is harder to get than malaria.Read more »
The return of chloroquine-sensitive Plasmodium falciparumto the limited area of Blantyre, Malawi, has been well demonstrated in several studies.
Insecticide-treated nets ownership and utilization among under-five children following the 2010 mass distribution in Burkina Faso
Ownership rates were high, but real access to bed nets remained limited.
Prevalence of asymptomatic malaria and bed net ownership and use in Bhutan, 2013: a country earmarked for malaria elimination
With high coverage and regular use of LLINs, and a zero prevalence of malaria infection found in historically high-risk communities during the peak malaria season, it appears Bhutan is on course to achieve malaria elimination.
Current methods of delivering ITNs, i.e., one mass campaign every five years and regular distribution of ITNs from health center can barely maintain the current effective coverage. Inaccessibility and loss of physical integrity of ITNs are major hindrances to achieving and maintaining universal coverage.
Long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) interventions can reduce malaria transmission by targeting mosquitoes when they feed upon sleeping humans and/or rest inside houses, livestock shelters or other man-made structures.Read more »