Impact of Artemisinin-Based Combination Therapy and Insecticide-Treated Nets on Malaria Burden in Zanzibar

Bhattarai et al. | 06 Nov 2007 | PloS Medicine

The Roll Back Malaria strategy recommends a combination of interventions for malaria control. Zanzibar implemented artemisinin-based combination therapy (ACT) for uncomplicated malaria in late 2003 and long-lasting insecticidal nets (LLINs) from early 2006. ACT is provided free of charge to all malaria patients, while LLINs are distributed free to children under age 5 y (''under five'') and pregnant women. We investigated temporal trends in Plasmodium falciparum prevalence and malaria-related health parameters following the implementation of these two malaria control interventions in Zanzibar.

HIV And Malaria Combine To Adversely Affect Pregnant Women And Their Infants

University of Toronto | 29 May 2007 | Science Daily

University of Toronto researchers have uncovered the basis by which pregnant women protect themselves against malaria and have also discovered how the HIV virus works to counteract this defence.

The safety of artemisinins during pregnancy: a pressing question

Stephanie Dellicour et al | 14 Feb 2007 | Malaria Journal

The limited data available suggest that artemisinins are effective and unlikely to be cause of foetal loss or abnormalities, when used in late pregnancy. However, none of these studies had adequate power to rule out rare serious adverse events

Dual Infection with HIV and Malaria Fuels the Spread of Both Diseases in Sub-Saharan Africa

Abu-Raddad et al. | 08 Dec 2006 | Science

Transient and repeated increases in HIV viral load resulting from recurrent co-infection with malaria may be an important factor in promoting the spread of HIV in sub-Saharan Africa.

Return of Chloroquine Antimalarial Efficacy in Malawi

Miriam K. Laufer et al | 09 Nov 2006 | New England Journal of Medicine

Dr. Nick White and Africa Fighting Malaria discuss the implications of a study on the efficacy of chloroquine in Malawi.

Manslaughter by Fake Artesunate in Asia - Will Africa Be Next?

Paul W. Newton et al | 13 Jun 2006 | PloS Medicine

Falciparum malaria kills, and it particularly kills the rural poor. Artemisinin derivatives, such as artesunate, are a vital component of Plasmodium falciparum malaria treatment and control in the face of globally increasing antimalarial drug resistance. Since 1998 a worsening epidemic of sophisticated counterfeit "artesunate" tablets (containing no artesunate) has plagued mainland Southeast Asia (see Figure S1). In some countries, most of the available artesunate is fake [1-5].