Research

Influence of Rapid Malaria Diagnostic Tests on Treatment and Health Outcome in Fever Patients, Zanzibar—A Crossover Validation Study

Mwinyi Msellem et al | 28 Apr 2009 | PloS Medicine

The use of rapid diagnostic tests (RDTs) for Plasmodium falciparum malaria is being suggested to improve diagnostic efficiency in peripheral health care settings in Africa.

Pilot study comparing technologies to test for substandard drugs in field settings

Roger Bate, Richard Tren, Kimberly Hess, Lorraine Mooney & Karen Porter | 27 Apr 2009 | African Journal of Pharmacy and Pharmacology

Researchers procured a range of antimalarial, antibiotic and antimycobacterial drugs from cities in six countries: Ghana, India, Kenya, Nigeria, Tanzania, and Uganda. Semi-quantitative thin-layer chromatography (TLC) and disintegration tests, Raman spectrometry, and near-infrared (NIR) spectrometry were used to measure the concentration of active ingredients and excipients (spectrometry only) to determine whether the tested samples were of good quality.

Antimalarial Drugs - Challenges and Suggestions for the Way Forward

None | 21 Apr 2009 | Africa Fighting Malaria

Roll Back Malaria's theme for World Malaria Day 2009 is "Counting Malaria Out". AFM supports the Roll Back Malaria Partnership in their efforts to improve data collection and track progress of malaria control efforts. For the past year, AFM and its partners have focused on "counting out" poor-quality antimalarial drugs.

Malaria misdiagnosis in Uganda - implications for policy change

Joan Nankabirwa et al | 16 Apr 2009 | Malaria Journal

In Uganda, like in many other countries traditionally viewed as harbouring very high malaria transmission, the norm has been to recommend that febrile episodes are diagnosed as malaria. In this study, the policy implications of such recommendations are revisited.

Home management of malaria with artemether-lumefantrine compared with standard care in urban Ugandan children: a randomised controlled trial

Sarah G Staedke et al | 14 Apr 2009 | The Lancet

Home management of malaria—the presumptive treatment of febrile children with antimalarial drugs—is advocated to ensure prompt effective treatment of the disease. We assessed the effect of home delivery of artemether-lumefantrine on the incidence of antimalarial treatment and on clinical outcomes in children from an urban setting with fairly low malaria transmission.

Review: Provider Practice and User Behavior Interventions to Improve Prompt and Effective Treatment of Malaria: Do We Know What Works?

Lucy A. Smith et al | 16 Mar 2009 | American Journal of Tropical Medicine and Hygiene

Effective case management of uncomplicated malaria is a cornerstone of successful malaria control. With current calls for the global elimination of malaria, all strategies to control malaria need to reach the highest achievable level of effective implementation.

The efficacy and safety of a new fixed-dose combination of amodiaquine and artesunate in young African children with acute uncomplicated Plasmodium falciparum

Sodiomon B Sirima et al | 16 Mar 2009 | Malaria Journal

Artesunate (AS) plus amodiaquine (AQ) is one artemisinin-based combination (ACT) recommended by the WHO for treating Plasmodium falciparum malaria. Fixed-dose AS/AQ is new, but its safety and efficacy are hitherto untested.

Physical and chemical stability of expired fixed dose combination artemether-lumefantrine in uncontrolled tropical conditions

Roger Bate, Richard Tren, Kimberly Hess & Amir Attaran | 25 Feb 2009 | Malaria Journal

New artemisinin combination therapies pose difficulties of implementation in developing and tropical settings because they have a short shelf-life (two years) relative to the medicines they replace. This limits the reliability and cost of treatment, and the acceptability of this treatment to health care workers. A multi-pronged investigation was made into the chemical and physical stability of fixed dose combination artemether-lumefantrine (FDC-ALU) stored under heterogeneous, uncontrolled African conditions, to probe if a shelf-life extension might be possible.

Household possession, use and non-use of treated or untreated mosquito nets in two ecologically diverse regions of Nigeria - Niger Delta and Sahel Savannah

Bamgboye M. Afolabi et al | 19 Feb 2009 | Malaria Journal

This study found that despite the fact that treated nets were distributed widely across Nigeria, the use of this commodity was still very low in the Sahel Savanna region. Future campaigns should include more purposeful social and health education on the importance and advantages of the use of treated nets to save lives in the Sahel Savannah region of Nigeria.

Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia

William Rogers et al | 12 Jan 2009 | Malaria Journal

Resistance to anti-malarial drugs hampers control efforts and increases the risk of morbidity and mortality from malaria. The efficacy of standard therapies for uncomplicated Plasmodium falciparum and Plasmodium vivax malaria was assessed in Chumkiri, Kampot Province, Cambodia.