Research

Impact of the large-scale deployment of artemether/lumefantrine on the malaria disease burden in Africa

Karen Barnes, Pascalina Chanda & Gebre Ab Barnabas | 12 Oct 2009 | Malaria Journal

Malaria is one of the most significant causes of morbidity and mortality worldwide. Every year, nearly one million deaths result from malaria infection.

Simple Field Assays to Check Quality of Current Artemisinin-Based Antimalarial Combination Formulations

Jean-Robert Ioset et al | 30 Sep 2009 | PLoS One

Malaria continues to be one of the major public health problems in Africa, Asia and Latin America. Artemisinin derivatives (ARTs; artesunate, artemether, and dihydroartemisinin) derived from the herb, Artemisia annua, are the most effective antimalarial drugs available providing rapid cures.

Combining Indoor Residual Spraying and Insecticide-Treated Net Interventions

Immo Kleinschmidt et al | 29 Sep 2009 | American Journal of Tropical Medicine and Hygiene

Does scaling up of malaria control by combining indoor residual spraying (IRS) and long-lasting insecticidal nets (LLIN) enhance protection to populations?

Do we still need a malaria vaccine?

B. Greenwood & G. Targett | 27 Aug 2009 | Parasite Immunology

An unexpectedly large reduction in the burden of malaria has recently been achieved in a number of malaria endemic countries following the scaling up of effective treatment and simple vector control programmes.

Efficacy of artesunate-amodiaquine for treating uncomplicated P. falciparum malaria in Sub-Saharan Africa: a multi-centre analysis

Julien Zwang et al | 23 Aug 2009 | Malaria Journal

Artesunate and amodiaquine (AS&AQ) is at present the world's second most widely used artemisinin-based combination therapies (ACT). Evaluating the efficacy of ACT recently adopted by the World Health Organisation (WHO) and deployed over 80 countries was necessary to make evidence base drug policy.

Drug Use in Nigeria

None | 29 Jul 2009 | Africa Fighting Malaria

For decades, Nigeria has been plagued by counterfeit and poor-quality medicines, yet little information exists on the extent to which healthcare personnel are aware of counterfeit and substandard medicines, and how this influences their behavior.

Decreased motivation in the use of insecticide-treated nets in a malaria endemic area in Burkina Faso

Lea Pare Toe et al | 29 Jul 2009 | Malaria Journal

The use of insecticide-treated nets (ITNs) is an important tool in the Roll Back Malaria strategy. For ITNs to be effective they need to be used correctly. Previous studies have shown that many factors, such as wealth, access to health care, education, ethnicity and gender, determine the ownership and use of ITNs.

Focusing on Quality Patient Care in the New Global Subsidy for Malaria Medicines

Suerie Moon et al | 21 Jul 2009 | PloS Medicine

Almost 40 years ago, Chinese scientists rediscovered the near-miraculous potency of artemisinin derivatives against malaria. Today, we are approaching a decade since the WHO recommended that ACTs replace older antimalarials rendered ineffective by resistance.

Fever treatment in the absence of malaria transmission in an urban informal settlement in Nairobi, Kenya

Yazoume Ye et al | 15 Jul 2009 | Malaria Journal

In sub-Saharan Africa, knowledge of malaria transmission across rapidly proliferating urban centres and recommendations for its prevention or management remain poorly defined.

Pilot Study of Essential Drug Quality in Two Major Cities in India

Roger Bate et al | 23 Jun 2009 | PLoS One

A pilot study was conducted in two major cities in India, Delhi and Chennai, to explore the question/hypothesis/extent of substandard and counterfeit drugs available in the market and to discuss how the Indian state and federal governments could improve drug regulation and more importantly regulatory enforcement to combat these drugs.