Research

A Lethal Subsidy

Roger Bate & Richard Tren | 08 Sep 2011 | American Enterprise Institute

By trying to do too much, the disease-fighting Global Fund has run into problems. It is spending public funds in a way that is perverting the market for malaria drugs and could do more harm than good.

Challenges and prospects for malaria elimination in the Southern Africa region

William J. Moss et al. | 07 Sep 2011 | Acta Tropica

The burden of malaria has decreased dramatically within the past several years in parts of sub-Saharan Africa, including regions of Southern Africa. 

Rapid whole genome optical mapping of Plasmodium falciparum

Matthew C Riley et al | 26 Aug 2011 | Malaria Journal

Immune evasion and drug resistance in malaria have been linked to chromosomal recombination and gene copy number variation (CNV).

Development of ELISA-based methods to measure the anti-malarial drug chloroquine in plasma and in pharmaceutical formulations

Insaf F Khalil et al | 24 Aug 2011 | Malaria Journal

The developed ELISA can be used for quality screening of CQ in pharmaceutical formulations and for drug monitoring in malaria and in other infectious diseases, such as HIV, where CQ proved to be an effective therapeutic agent. The methodology has been exploited to develop monoclonal antibodies for the drugs used in artemisinin-based combination therapy (ACT).

A cluster-randomized trial of mass drug administration with a gametocytocidal drug combination to interrupt malaria transmission in a low endemic area in Tanzania

Seif A Shekalaghe et al | 24 Aug 2011 | Malaria Journal

Effective mass drug administration (MDA) with anti-malarial drugs can clear the human infectious reservoir for malaria and thereby interrupt malaria transmission.

Repeated treatment of recurrent uncomplicated Plasmodium falciparum malaria in Senegal with fixed-dose artesunate plus amodiaquine versus fixed-dose artemether plus lumefantrine: a randomized, open-label trial

Jean-Louis A Ndiaye et al | 12 Aug 2011 | Malaria Journal

Study results confirmed the satisfactory efficacy and safety profile of ASAQ and AL. Moreover, in patients who were treated at least twice, repeated administration of ASAQ or AL did not identify any major safety issues.

Malaria elimination in Isabel Province, Solomon Islands: establishing a surveillance-response system to prevent introduction and reintroduction of malaria

Matthew J O'Sullivan et al | 11 Aug 2011 | Malaria Journal

The Solomon Islands National Malaria Programme is currently focused on intensified control and progressive elimination.

Designing a sustainable strategy for malaria control?

Clive Shiff et al | 03 Aug 2011 | Malaria Journal

Malaria in the 21st century is showing signs of declining over much of its distribution, including several countries in Africa where previously this was not thought to be feasible.

Determinants of bed net use in children under five and household bed net ownership on Bioko Island, Equatorial Guinea

Alberto L Garcia-Basteiro et al | 29 Jun 2011 | Malaria Journal

As part of comprehensive malaria control strategies, the Bioko Island Malaria Control Project (BIMCP) distributed 110,000 long-lasting insecticide-treated nets (LLIN) in late 2007 with the aim of providing one net for each sleeping area.

Relationship between care-givers' misconceptions and non-use of ITNs by under-five Nigerian children

Ekundayo Arogundade et al | 22 Jun 2011 | Malaria Journal

Misconceptions about causes and prevention of malaria by caregivers adversely influence the use ITN by under-five children. Appropriate communication strategies should correct these misconceptions.