Research
CATEGORIES
General
Malaria Vector Control
Malaria Treatment

Rolling Back a Malaria Epidemic In South Africa  - Patrick Duffy et al.
This new paper in Public Library of Science details the successful strategies that South Africa implemented to control a malaria epidemic - Indoor Residual Spraying with DDT and new artemesinin-based combination therapies.

IMMTECH COMMENCES PHASE IIB MALARIA TRIAL  - Immtech Press Release
Immtech and the Medicines for Malaria Venture has started phase IIb trials on a new malaria drug - known as DB 289.

Efficacy of the RTS,S/AS02A vaccine against Plasmodium falciparum infection and disease in young African children: randomised controlled trial  - Pedro L Alonso, Jahit Sacarlal, John J Aponte et al.
"The RTS,S/AS02A vaccine was safe, well tolerated, and immunogenic. Our results show development of an effective vaccine against malaria is feasible. "

Efficacy of rectal artesunate compared with parenteral quinine in initial treatment of moderately severe malaria in African children and adults: a randomoised study  - K I Barnes et al
The Lancet publishes Karen Barnes' research which shows that a single rectal dose of artesunate is associated with rapid reduction in parasie density in adults and children with moderately severe malaria, within the initial 24 h of treatment. This option is useful for initiation of treatment in patients unable to take oral medication, particularly where parenteral treatment is unavailable.

WHO, the Global Fund, a medical malpractice in malaria treatment  - Amir Attaran et al.
Amir Attaran and a group of leading malaria scientists accuse the Global Fund and the WHO of medical malpractice for sanctioning and paying for failed malaria drugs in Africa while better drugs are available

Dihydroartemisinin-piperaquine against multidrug-resistant Plasmodium falciparum malaria in Vietnam: randomised clinical trial  - Tran Tihn Hien et al.
In South East Asia, where malaria drug resistance is rife, researchers find that 'Dihydroartemisinin-piperaquine is an inexpensive, safe, highly efficacious fixed-dose antimalarial combination treatment that could make an important contribution to the control of multidrug-resistant falciparum malaria.'

Artesunate combinations for treatment of malaria: a meta analysis  - International Artemesinin Study Group
The International Artemesinin Study Group finds that the addition of artemisinin derivatives to existing drug regimens for malaria could reduce treatment failure and transmission potential. We assessed the evidence for this hypothesis from randomised controlled trials.

Counterfeit Artesunate antimalarials in South East Asia  - Paul N Newton, Arjen Dondorp, Michael Green, Mayfong Mayxay, *Nicholas J White
The trade in fake drugs has always been a problem in South East Asia. When artesunate drugs are the only effective antimalarial available in many countries, stopping the trade in fake drugs and the danger that resistance will develop as a result is vital. Read The Lancet's Paper exposing this problem.

AGOA Conference, Workshop on Health Infrastructure  - Richard Tren
Read Richard Tren's comments to the Africa Growth and Opportunities Act meeting in Mauritius, January 2003.

TRIPS and Access to Healthcare  - Richard Tren
Richard Tren discusses the controversy over the WTO TRIPS agreement and its affect on access to drugs in poor countries. Tren is sceptical that TRIPS is a major barrier to access given the more fundamental barriers such as poverty, a lack of infrastructure and the poor political will in Africa to deal with the problem

Link to WHO, the Global Fund, and medical malpractice in malaria treatment. The Lancet